Cancer adaptations: Atavism, de novo selection, or something in between?
Identifieur interne : 001056 ( Main/Exploration ); précédent : 001055; suivant : 001057Cancer adaptations: Atavism, de novo selection, or something in between?
Auteurs : Frédéric Thomas [France] ; Beata Ujvari [Australie] ; François Renaud [France] ; Mark Vincent [Canada]Source :
- BioEssays : news and reviews in molecular, cellular and developmental biology [ 1521-1878 ] ; 2017.
Abstract
From an evolutionary perspective, both atavism and somatic evolution/convergent evolution theories can account for the consistent occurrence, and astounding attributes of cancers: being able to evolve from a single cell to a complex organized system, and malignant transformations showing significant similarities across organs, individuals, and species. Here, we first provide an overview of these two hypotheses, including the possibility of them not being mutually exclusive, but rather potentially representing the two extremes of a continuum in which the diversity of cancers can emerge. In reviewing the current literature, we also discuss the criteria that should be applied to discriminate between the two competing theories and to determine their relevant contributions to oncogenesis and cancer progression. Finally, we deliberate on the potential applications of this conceptual framework in developing novel treatment strategies.
DOI: 10.1002/bies.201700039
PubMed: 28691339
Affiliations:
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account for the consistent occurrence, and astounding attributes of cancers: being able to evolve from a single cell to a complex organized system, and malignant transformations showing significant similarities across organs, individuals, and species. Here, we first provide an overview of these two hypotheses, including the possibility of them not being mutually exclusive, but rather potentially representing the two extremes of a continuum in which the diversity of cancers can emerge. In reviewing the current literature, we also discuss the criteria that should be applied to discriminate between the two competing theories and to determine their relevant contributions to oncogenesis and cancer progression. Finally, we deliberate on the potential applications of this conceptual framework in developing novel treatment strategies.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name></noRegion><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name></country><country name="Australie"><noRegion><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Vincent, Mark" sort="Vincent, Mark" uniqKey="Vincent M" first="Mark" last="Vincent">Mark Vincent</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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